Home > Field of Cooperation > Climate Change＆Health > Uncovering the burden of asymptomatic malaria: dissecting immune responses to infection to overcome immunosuppression and improve vaccination strategies
Uncovering the burden of asymptomatic malaria: dissecting immune responses to infection to overcome immunosuppression and improve vaccination strategies |
| Principal Investigator / Affiliation | Diana Silvia Hansen (Prof/Laboratory Head) / Monash Biomedicine Discovery Institute  Australia |
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Indra Wibowo (Dr/Assistant Professor) / School of Life Sciences and Technology, Bandung Institute of Technology  Indonesia |
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Takafumi Tsuboi (Distinguished Professor) / Ehime University  Japan |
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Stephen Hoffman (Chief Scientific and Executive Officer) / Sanaria Inc  USA |
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| Year Adopted | 2023 |
| Research Period | 3 years |
| General Description of the Research Project | This cooperative research project aims to undertake a comprehensive immunological and molecular analysis of individuals experiencing asymptomatic malaria in an endemic area of Indonesia. The project will uncover that these non-febrile infections cause strong immunosuppression, are not benign as previously thought, and prevent the host to efficiently control infection and respond to immunization. Our research will also allow us to identify critical immune responses to eradicate these persistent infections through innovative attenuated whole parasite vaccination strategies. |
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Researchers
| Principal Investigator / Country of Research Team | 
Diana Silvia Hansen Australia
Indra Wibowo Indonesia
Takafumi Tsuboi Japan
Stephen Hoffman the United States |
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