Researchers
Name (Institute) |
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| Specialty | 1. Development techniques for visualization analysis of chromosome structure and function 2. Localization and functional analysis of chromosomal protein and gene 3. New techniques of scanning electron microscope (SEM), focused ion beam-SEM (FIB/SEM), focused Ne+ ion beam/He+ ion microscopy (Ne-FIB/HIM), 3D scanning transmission electron microscope (3D-STEM). |
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| Science Interest (Past) |
Bio-nanotechnology and cell biology will focus on chromosomes and microorganisms. Chromosome is made up of DNA tightly coiled around structural protein. Chromosome plays an important role to carry genetic information. Function and structure are both important for biological science. However, ordinary methods including molecular biology struggle to elucidate the inner structure of both chromosomes and nuclei which have remained an enigma since it discovery during the late 19th century. | ||||
| Science Interest (Current) |
I am seeking to analyze chromatin of plants and both micro and macrochromosomes of reptiles. Especally, plants have characteristic chromosomes constructed with both euchromatin and heterochromatin regions. The heterochromatin associated with specific histone post-translational modifications, producing a closed chromatin configuration that limits the access of transcriptional machinery. Histone modification related to heterochromatin have been well studied in various group of plants. But how chromatin is organized in heterochromatin is less understood. They are often indistinguishable by ordinarily visualization methods including optical microscopy. Chromosome structure has been investigated using molecular biology, genetic analyses and advanced nano-visualization at Kobe University, Japan. | ||||
| Science Interest (Future) |
Study of chromatin organization, or chromosome inner structure in higher scope, will give a new insight for many biological phenomena, particularly to portray the specific mechanism of gene expression. Furthermore, this research will provide better understanding on evolutionary and phylogenetic study among eukaryotic organisms, as different structure of chromatin organization may give a clue to the empirical evidence of biological processes. These investigations will contribute to the study of the evolution, structure and abnormal occurrences of animal and plants chromosomes. | ||||
| Website / Contact | http://www2.kobe-u.ac.jp/~ohmido/Ohmido%20Lab/index.html |
